NOTE: In Fall 2020, curricular changes required  a complete redeisgn of Patho Pharm 1 and 2.  The original versions are preserved at https://patheyman.com/nursing/courses/patho-pharm-1-old

Below are the topics, handouts, and notes for Pathophysiology and Pharmacology I. Click on the lecture boxes to see the lecture files (mp3) for that topic. Alternatively, you may download the lectures as a zip file or subscribe as a podcast.

Patho Pharm 1: Podcast Feed Subscribe with iTunes Download as Zip File (392 MB)

Overall Course Materials

Test Guides

Test 1

The test is approximately half Intro/Basic Pharmacology and half Neuro.  Expect a couple matching questions, such as matching drugs to their mechanisms of action or to their therapeutic use or their adverse effects.  For every drug you need to know, you should know at minimum: class, mechanism of action, therapeutic effects, therapeutic use (what conditions is it used for), adverse effects, appropriate assessments, major interactions, and teaching points.  Some content to think about:

  • Oxycodone vs Oxycontin
  • Long acting medications (XL, LA, CR, etc.)
  • Potency vs Efficacy
  • Therapeutic range and therapeutic index
  • Pharmacokinetics vs Pharmacodynamics
  • Know all of the routes (not just PO, IV, IM, SQ; know the broader category: enteral, parenteral and their implications)
  • topical vs transdermal
  • Recognize different kinds of etiology of disease (pro tip: idiopathic means you don’t know that actual etiology)
  • OTC vs Rx vs Scheduled drugs; difference between Schedule II and III.
  • Cytochrome P-450 Enzymes; reason out the net result
  • Creatinine and creatinine clearance.  (when is each one appropriate)
  • Basic Neuron physiology: resting, action potential
  • Neuromuscular function: myasthenia gravis and Nicotnic-M blockers
  • Malignant hyperthermia
  • Basic sympathetic and parasympathetic function.
  • Anticholinergics: effects, which drugs are used, adverse effects
  • Catecholamines vs sympathemimetics: what each one is used for; adverse effects
  • Shock: different kinds and treatments
  • Heart failure: inotropic (catecholamines) vs beta blockers
  • Beta blockers, beta blockers, and more beta blockers.  Metoprolol will be one of the drugs you see most often in practice.
  • Alpha blockers: three therapeutic uses and adverse effects
  • What’s a pheochromocytoma, and how is it treated?

Test 2

Expect at least one question on each drug class. Usually on the big things talked about, so for example

  • Vanco: what makes it special, what is it used for, how is it absorbed, major adverse effects, how is it given and monitored
  • Flagyl: what is it used for, what’s the major adverse effect, what is the major interaction
  • Linezolid: what is it used for? What is the major interaction, what are the food issues?
  • Understand the four basic mechanisms of bacterial resistance
  • Understand the CDC recommendations to reduce bacterial resistance
  • Know the difference between colonization and infection
  • Know the local and systemic signs and symptoms of infection
  • Know the WBC levels and Neutrophils/Bands
  • Know the difference between shift left/right
  • Why is strep throat a big deal?
  • What are the alternatives to penicillin?
  • C. diff, causes and treatments
  • The less time we spent on a drug, the fewer questions will likely be on it.
  • UTI types and drugs
  • Know the types of Hepatitis, how they’re transmitted, which ones can become chronic, and which ones have a vaccine

There will be a question on this new Hepatis C drug: http://www.everydayhealth.com/hepatitis/1209/new-hepatitis-c-drug-approved-by-fda.aspx

Here are the flu articles that I mentioned: http://www.americanthinker.com/2009/05/swine_flu_in_perspective.html http://www.americanthinker.com/2009/10/swine_flu_panic_in_perspective.html

Test 3

~60 questions Half immune/inflammation and Half pain Also about half patho, half pharm

Generally speaking there will be at least one question on every major topic: So for the immune system things like:

  • Fluid balance (edema control)
  • Inflammatory mediators
  • Complement
  • WBCs of various types
  • Differences between T cells
  • Life cycle of a T cell
  • Same for B cells
  • Four types of antibodies and purpose of each type
  • Four functions of antibodies
  • Types of vaccines
  • Septic Shock
  • DIC
  • Hypersensitivity
  • Wound healing
  • How the immune and inflammatory side work together
  • Pain Tolerance/Threshold
  • Acute/Chronic Pain
  • Steps in pain process
  • Principles of Pain management
  • Addiction
  • All the drugs

Some things in the reading/podcasts that you should know that we did not cover in class

  • Pyrogens
  • Lab tests for inflammation
  • Article on IV Acetaminophen
  • Finally, Do the So You Think You’re Good Quiz on my website (through pain)
  • Contemporary Addiction Model (starts at minute 27 in the video below).

Test 4

70 questions. 35 on Fluids and Electrolytes and 35 on Respiratory. About half patho and half pharm.

  1. Know your lab values
  2. Know the drugs
  3. Know signs/symptoms of fluid overload and dehydration
  4. Know the major s/s for each electrolyte imbalance.
  5. Know the treatments for each electrolyte imbalance.
  6. Pay particular attention to potassium and calcium
  7. Know your abgs
  8. UNDER NO CIRCUMSTANCES CONFUSE CO2 FOR PaCO2
  9. Know what the implications of acidosis and alkalosis are
  10. Know the basic respiratory A&P
  11. Know at least the names and basic definition of each resp response to disease
  12. Know the basic pathophysiology of Asthma, Emphysema, and Chronic Bronchitis
  13. Review things from previous chapters that might be applicable such as antibiotics and sympathetic response

Some General Tips:

  1. Read the question, and make sure you are answering what it is asking, and not what you THINK it’s asking.
  2. On a short answer, less is more. If I ask for a treatment, just give me the treatment. On the other hand, if I ask you to interpret AND give a treatment, make sure you do both.
  3. You have scratch paper for a reason. You don’t need to explain every detail of why you think the ABG is that. Do that part on your paper, and then just put down the answer in the computer. Partial credit is already built into the answer, so showing your work doesn’t get you any more points.

Test 5

Anemias and Clotting. about 60 questions. Half of each.

This test is quite small in amount of content which makes it easier, BUT that also means that the test will be more detailed. You absolutely need to be able to interpret lab values and know of your drugs!!!!

  1. know your lab values
  2. know the calculations for heparin:
    1. calculate kg: divide pounds by 2.2;
    2. calculate unit dose: multiply the weight based dose by the weight
    3. calculate the mL dose: divide the unit dose by the concentration
  3. be ready to interpret CBCs!!!!
  4. READ THE QUESTION.
  5. On the short answer ONLY answer what’s being asked.
  6. On the short answer make sure you answer all parts of a multi part question. (e.g. interpret AND give a treatment)
  7. morphology of cbc refers to -cytic -chromic
  8. know the major aspects of hematopoiesis
  9. know the common s/s of anemia and compensatory mechanism
  10. know each type of anemia and its treatment
  11. know the ANC and neutropenia precautions
  12. know therapeutic ranges for heparin and warfarin (different for different types of problem)
  13. know the basic physiololgy of clotting
  14. know the major thromboembolic d/o’s, esp MI,AAA, AF, Stroke, DVT, PE.
  15. answer what the question is asking.
  16. know the difference between antiplatelets, anticoagulants, and thrombolytics.
  17. know blood transfusions and different blood products. know which ones are pooled (i.e., more than one donor per unit) and why that’s important.

A couple things that don’t always get mentioned class:

  1. Aplastic Anemia comes in two forms
    1. Pure RBC Aplasia
    2. Pancytopenia (when RBCs, WBCs, AND platelets are all three low)
  2. Too many RBCS
    1. Polycythemia (often an adaptation to poor oxygenation or living at elevation)
    2. Polycythemia vera (RBCs, WBC, AND Platelets high) usually precursor to cancer

Final exam

There are 110 questions plus a few short answer.

If I were you, I would take the quizzes and study all the questions I got wrong and the ones that I wasn’t sure about. Then I would do the So You Think You’re Good.

More or less 10 questions each on the following topics: 1.Intro Know the definitions, Pharmacokinetics, Therapeutic index, range, efficacy versus potency, etc.

2. Neuro basic physiology drugs and uses myasthenia gravis

3. Antibiotics

4. Inflammation purpose/basic physiology Signs, symptoms, lab tests such as ESR, CRP, WBCs, fever, etc Major mediators such as leukotrienes, histamine, prostaglandins, etc. Role of complement: MAC, opsonization, activation pathways Antibodies/B cells T cells Other White blood cells TNF-alpha Septic Shock

5. Pain Know the major drug classes as well as individual drugs discussed in class and listed on drug table Know the physiology of pain Know the major pain management strategies. Don’t give too much acetominopen

6. Electrolyte imbalances Normal values etiology/signs/symptoms/treatments Fluids ABGs

7. Respiratory COPD/asthma/pneumonia in detail definitions of others e.g. bronchiolitis, bronchiectasis ARDS: risk factors, screening, diagnosis, death ABGs hyper capnea: increase K+ –> ecg problems, incr. cerebral dilation –> ICP –> somnolence, coma, death

8. Anemias etiology, s/s/, treatment normal values

9. Bleeding/clotting basic physiology drugs therapeutic applications


Unit 1 Introduction

Note:  The Introduction to Pharmacology and Fluid & Electrolytes are no longer part of Patho Pharm.  Intro is now included as part of Fundamentals of Nursing, and F&E and Acid Base are now included as part of Medical Surgical Nursing I.  They are included here as references, and you’ll be expected to know that material throughout Patho Pharm 1 and 2.

The Fundamentals Introduction Pharmacology is also missing a few slightly more complex topics such as Cytochrome P-450.  The VoiceThread contains the original full Introduction.  The videos show the new slimmed Fundamentals versions.

Topics Include:

  • Pathophysiology Terms and Concepts
  • Pharmacology Terms and Concepts

Class notes:

Introduction Lectures:

Intro VoiceThread

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Introduction to Pharmacology Video

https://youtu.be/keBkkISX0ao

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Pharmacology in Long Term Care and Common Drugs Video

https://youtu.be/6y3GoTKovhw


Unit 1.1: Fluid & Electrolytes and Acid Base Balance

Note: This Unit is not technically part of Patho Pharm 1.  It is now included in Medical-Surgical Nursing I Theory.  That said, I DO expect your to know this material for the course.  So I’ve included it here.

  • Fluid physiology and types of fluids
  • Electrolyte interpretation and medications
  • Acid Base Balance

Class Handouts:

Class notes:

Lectures

Fluids and Electrolytes

Fluids and Electrolytes 1: Definitions, normal values, Fluid spaces, Basic fluid physiology, osmosis and diffusionhttp://patheyman.com/sites/default/files/nursing/lectures/06-patho-pharm1-electrolytes-01.mp3Fluids and Electrolytes 2: Fluid physiology cont, Blood pressure, distribution, organs and control, Assessmenthttp://patheyman.com/sites/default/files/nursing/lectures/06-patho-pharm1-electrolytes-02.mp3Fluids and Electrolytes 3: Dehydration and Fluid Overload, Sodium imbalances, Fluid replacement solutionshttp://patheyman.com/sites/default/files/nursing/lectures/06-patho-pharm1-electrolytes-03.mp3Fluids and Electrolytes 4: Electrolytes, BMP interpretation, Potassium, Calcium, Magnesium, Sodiumhttp://patheyman.com/sites/default/files/nursing/lectures/06-patho-pharm1-electrolytes-04.mp3Fluids and Electrolytes 5: Potassium imbalances and treatments, Calcium imbalances and treatments (more detail in Patho-pharm 2)http://patheyman.com/sites/default/files/nursing/lectures/06-patho-pharm1-electrolytes-05.mp3

Acid Base

Acid Base 1: Normal Acid-base physiology and buffers, ABG interpretationhttp://patheyman.com/sites/default/files/nursing/lectures/06-patho-pharm1-electrolytes-06.mp3Acid Base 2: ABG interpretation continuedhttp://patheyman.com/sites/default/files/nursing/lectures/06-patho-pharm1-electrolytes-07.mp3Acid Base 3: Respiratory acidosishttp://patheyman.com/sites/default/files/nursing/lectures/06-patho-pharm1-electrolytes-08.mp3Acid Base 4: ABG interpretation exampleshttp://patheyman.com/sites/default/files/nursing/lectures/06-patho-pharm1-electrolytes-09.mp3

Review

Fluid and Electrolytes – Acid Base Reviewhttp://patheyman.com/sites/default/files/nursing/lectures/06-patho-pharm1-electrolytes-10.mp3

VoiceThread - Electrolytes and Acid/Base

Video - Fluid and Electrolytes

https://www.youtube.com/watch?v=ShQNHsxRDEQ

Vidoe: ABGs and Acid/Base

https://www.youtube.com/watch?v=muxujtLFWI8

 


Unit 2: Introduction to Parasympathetic and Sympathetic Response

I am including the full Peripheral Neuro lectures for the sake of completeness for those of you who are nerds.  But the only testable material in Patho Pharm I will be the introduction to Sympathetic Response and alpha and beta-blockers (and clonidine).  The other drugs will mainly be presented in Patho Pharm 2.  (There is one exception.  You’ll need to know atropine for anti-diarrheals.)  Eventually, I’ll get around to cutting this material down to just what you need, but for now…there’s no kill like overkill.

Topics Include

  • Basic Neuro physiology
  • Divisions of Nervous System
  • Pharmacology of Peripheral Nervous System

Class Handouts:

Class notes:

Neuro Lectures

Peripheral Neuro Introduction

Neuro 1 Intro: Anatomy of the nervous system. Neuron structure and transmission. Synaptic transmission.http://patheyman.com/sites/default/files/nursing/lectures/02-patho-pharm1-neuro-01.mp3Neuro 2 Intro: Receptor interactions, Sympathetic and parasympathetic, Neurotransmittershttp://patheyman.com/sites/default/files/nursing/lectures/02-patho-pharm1-neuro-02.mp3Neuro 3 Intro:http://patheyman.com/sites/default/files/nursing/lectures/02-patho-pharm1-neuro-03.mp3Neuro 4 Introhttp://patheyman.com/sites/default/files/nursing/lectures/02-patho-pharm1-neuro-04.mp3Neuro 5 Introhttp://patheyman.com/sites/default/files/nursing/lectures/02-patho-pharm1-neuro-05.mp3

Neuro Pharmacology

Neuro 6 Pharmhttp://patheyman.com/sites/default/files/nursing/lectures/02-patho-pharm1-neuro-06.mp3Neuro 7 Pharmhttp://patheyman.com/sites/default/files/nursing/lectures/02-patho-pharm1-neuro-07.mp3Neuro 8 Pharmhttp://patheyman.com/sites/default/files/nursing/lectures/02-patho-pharm1-neuro-08.mp3Neuro 9 Pharmhttp://patheyman.com/sites/default/files/nursing/lectures/02-patho-pharm1-neuro-09.mp3Neuro 10 Pharmhttp://patheyman.com/sites/default/files/nursing/lectures/02-patho-pharm1-neuro-10.mp3Neuro 11 Pharmhttp://patheyman.com/sites/default/files/nursing/lectures/02-patho-pharm1-neuro-11.mp3Neuro 12 Pharmhttp://patheyman.com/sites/default/files/nursing/lectures/02-patho-pharm1-neuro-12.mp3Neuro 13 Pharmhttp://patheyman.com/sites/default/files/nursing/lectures/02-patho-pharm1-neuro-13.mp3Neuro 14 Pharmhttp://patheyman.com/sites/default/files/nursing/lectures/02-patho-pharm1-neuro-14.mp3

VoiceThread: Neuro Drugs

VoiceThread: Neuro Drugs

New Lectures: Neuro Intro Video

https://www.youtube.com/watch?v=fxZQxXmX08U

New Lectures: Neuro Drugs Part 1 Video

https://www.youtube.com/watch?v=HtGaXWwCfWE

New Lectures: Neuro Drugs Part 2 Video

https://www.youtube.com/watch?v=xhzU5kWTOdk

 


Unit 4 Introduction to Inflammation

Previously, this module covered both Inflammation and Immunity.  In the updated course, this is ONLY an introduction to Inflammation, BUT for now, everything is included in the lecture..  This module covers the cells and organs of the immune system, inflammatory processes, and their control mechanisms. It also covers infections and allergies (hypersensitivity reactions).

Class Handouts:

Class notes:

Inflammation and Immunity Lectures


Inflammation and Immunity Lectures

Inflammation and Immunity 1: Fluid physiology and edemahttp://patheyman.com/sites/default/files/nursing/lectures/03-patho-pharm1-inflamm-01.mp3Inflammation and Immunity 2: Inflammation in general; S/Shttp://patheyman.com/sites/default/files/nursing/lectures/03-patho-pharm1-inflamm-02.mp3Inflammation and Immunity 3: Zymogens, White Blood Cellshttp://patheyman.com/sites/default/files/nursing/lectures/03-patho-pharm1-inflamm-03.mp3Inflammation and Immunity 4: Recap, Inflammation vs Immunity, Adaptive (or Specific) Immune Systemhttp://patheyman.com/sites/default/files/nursing/lectures/03-patho-pharm1-inflamm-04.mp3Inflammation and Immunity 5: WBCs continued, Lymphocytes, Basic Immune processhttp://patheyman.com/sites/default/files/nursing/lectures/03-patho-pharm1-inflamm-05.mp3Inflammation and Immunity 6: Antibodies and B cells, Antigens, MHC, Complementhttp://patheyman.com/sites/default/files/nursing/lectures/03-patho-pharm1-inflamm-06.mp3Inflammation and Immunity 7: The big picture. Interplay of Inflammation and Immunity, Cell mediated and humoral immunityhttp://patheyman.com/sites/default/files/nursing/lectures/03-patho-pharm1-inflamm-07.mp3Inflammation and Immunity 8: Types of shock. Memory, vaccineshttp://patheyman.com/sites/default/files/nursing/lectures/03-patho-pharm1-inflamm-08.mp3Inflammation and Immunity 9: Recap and the big picture, Healing and Woundshttp://patheyman.com/sites/default/files/nursing/lectures/03-patho-pharm1-inflamm-09.mp3Inflammation and Immunity 10: Age related changes and other factors affecting healing, Hypersensitivity reactions.http://patheyman.com/sites/default/files/nursing/lectures/03-patho-pharm1-inflamm-10.mp3Inflammation and Immunity 11: Hypersensitivity reactions continued, Measures of immune function and lab values.http://patheyman.com/sites/default/files/nursing/lectures/03-patho-pharm1-inflamm-11.mp3Inflammation and Immunity 12: Anti-inflammatories: Antihistamine, NSAIDS (no detail), Steroids, Immunosuppressantshttp://patheyman.com/sites/default/files/nursing/lectures/03-patho-pharm1-inflamm-12.mp3Inflammation and Immunity 13: Steroids continuedhttp://patheyman.com/sites/default/files/nursing/lectures/03-patho-pharm1-inflamm-13.mp3

VoiceThread

New Lectures: Inflammation Part 1

You should watch the first 2 hours of this video.https://www.youtube.com/watch?v=kkw-jLHeBWI

New Lectures: Neuro Drugs Part 2

Watch Steroids: 1:25 to end.https://www.youtube.com/watch?v=tEA0OLugINA


Unit 3 Antibiotics and Infections

This module covers antibiotics, antifungals, and antimicrobials as well as general infection topics. You will need to know that fever and high WBCs are associated with infection.
Class Handouts:

Class notes:

Antibiotics Lectures

Antibiotics

Antibiotics 1: Cell walls and Penicillins, Resistancehttp://patheyman.com/sites/default/files/nursing/lectures/03-patho-pharm1-antibiotics-01.mp3Antibiotics 2: Penicillinshttp://patheyman.com/sites/default/files/nursing/lectures/03-patho-pharm1-antibiotics-02.mp3Antibiotics 3 Cephalosporins, “Intro to Antibiotics”, CDC 12 steps to prevent bacterial resistance.http://patheyman.com/sites/default/files/nursing/lectures/03-patho-pharm1-antibiotics-03.mp3Antibiotics 4: Inhibitors of Protein Synthesis, Tetracycline, Macrolides, Clindamycinhttp://patheyman.com/sites/default/files/nursing/lectures/03-patho-pharm1-antibiotics-04.mp3Antibiotics 5: Linzeolid (and MAO inhibition), Aminoglycosideshttp://patheyman.com/sites/default/files/nursing/lectures/03-patho-pharm1-antibiotics-05.mp3Antibiotics 6: Sulfonamides, Fluoroquinolones, UTIsTuberculosis drugshttp://patheyman.com/sites/default/files/nursing/lectures/03-patho-pharm1-antibiotics-06.mp3Antibiotics 7: Antifungalshttp://patheyman.com/sites/default/files/nursing/lectures/03-patho-pharm1-antibiotics-07.mp3Antibiotics 8: Antivirals, Herpes, Zoster, CMV, Hepatitishttp://patheyman.com/sites/default/files/nursing/lectures/03-patho-pharm1-antibiotics-08.mp3Antibiotics 9: Hepatitis Continued, Fluhttp://patheyman.com/sites/default/files/nursing/lectures/03-patho-pharm1-antibiotics-09.mp3

VoiceThread

 

 


Unit 4 Inflammation and Pain

This module covers the cells and organs of the immune system, inflammatory processes, and their control mechanisms. It also covers infections and allergies (hypersensitivity reactions).

Class Handouts:

Class notes:

Inflammation and Immunity Lectures


Inflammation and Immunity Lectures

Inflammation and Immunity 1: Fluid physiology and edemahttp://patheyman.com/sites/default/files/nursing/lectures/03-patho-pharm1-inflamm-01.mp3Inflammation and Immunity 2: Inflammation in general; S/Shttp://patheyman.com/sites/default/files/nursing/lectures/03-patho-pharm1-inflamm-02.mp3Inflammation and Immunity 3: Zymogens, White Blood Cellshttp://patheyman.com/sites/default/files/nursing/lectures/03-patho-pharm1-inflamm-03.mp3Inflammation and Immunity 4: Recap, Inflammation vs Immunity, Adaptive (or Specific) Immune Systemhttp://patheyman.com/sites/default/files/nursing/lectures/03-patho-pharm1-inflamm-04.mp3Inflammation and Immunity 5: WBCs continued, Lymphocytes, Basic Immune processhttp://patheyman.com/sites/default/files/nursing/lectures/03-patho-pharm1-inflamm-05.mp3Inflammation and Immunity 6: Antibodies and B cells, Antigens, MHC, Complementhttp://patheyman.com/sites/default/files/nursing/lectures/03-patho-pharm1-inflamm-06.mp3Inflammation and Immunity 7: The big picture. Interplay of Inflammation and Immunity, Cell mediated and humoral immunityhttp://patheyman.com/sites/default/files/nursing/lectures/03-patho-pharm1-inflamm-07.mp3Inflammation and Immunity 8: Types of shock. Memory, vaccineshttp://patheyman.com/sites/default/files/nursing/lectures/03-patho-pharm1-inflamm-08.mp3Inflammation and Immunity 9: Recap and the big picture, Healing and Woundshttp://patheyman.com/sites/default/files/nursing/lectures/03-patho-pharm1-inflamm-09.mp3Inflammation and Immunity 10: Age related changes and other factors affecting healing, Hypersensitivity reactions.http://patheyman.com/sites/default/files/nursing/lectures/03-patho-pharm1-inflamm-10.mp3Inflammation and Immunity 11: Hypersensitivity reactions continued, Measures of immune function and lab values.http://patheyman.com/sites/default/files/nursing/lectures/03-patho-pharm1-inflamm-11.mp3Inflammation and Immunity 12: Anti-inflammatories: Antihistamine, NSAIDS (no detail), Steroids, Immunosuppressantshttp://patheyman.com/sites/default/files/nursing/lectures/03-patho-pharm1-inflamm-12.mp3Inflammation and Immunity 13: Steroids continuedhttp://patheyman.com/sites/default/files/nursing/lectures/03-patho-pharm1-inflamm-13.mp3

VoiceThread

New Lectures: Neuro Drugs Part 1

https://www.youtube.com/watch?v=kkw-jLHeBWI

New Lectures: Neuro Drugs Part 2

https://www.youtube.com/watch?v=tEA0OLugINA


Unit 5 Pain

Anatomy and Physiology of pain, non pharmacologic measures, and drugs used in pain management:

  • Anesthetics
  • NSAIDS
  • Acetaminophen
  • Opioids

Class notes:

Pain Lectures


Pain Lectures

Pain 1: Pain definitions and transmissionhttp://patheyman.com/sites/default/files/nursing/lectures/04-patho-pharm1-pain-01.mp3Pain 2: Theory of Pain, Pain physiology continued, Acute vs Chronic Painhttp://patheyman.com/sites/default/files/nursing/lectures/04-patho-pharm1-pain-02.mp3Pain 3: Pain Management; nonpharmacologic; pharmacological, Local anesthetics, Opioids, Narcanhttp://patheyman.com/sites/default/files/nursing/lectures/04-patho-pharm1-pain-03.mp3Pain 4: Off-topic (Transplants), Morphine (detail)http://patheyman.com/sites/default/files/nursing/lectures/04-patho-pharm1-pain-04.mp3Pain 5: Morphine (detail continued), Narcan, Pain management, ICPhttp://patheyman.com/sites/default/files/nursing/lectures/04-patho-pharm1-pain-05.mp3Pain6: Pain management schedules and techniques (Routine, PRN, PCA), Tolerance, Addictionhttp://patheyman.com/sites/default/files/nursing/lectures/04-patho-pharm1-pain-06.mp3Pain 7: Prostaglandins, Inflammation, NSAIDS, ASA, Acetaminophenhttp://patheyman.com/sites/default/files/nursing/lectures/04-patho-pharm1-pain-07.mp3Pain 8: COX-2 inhibitors, OTC pain medicationshttp://patheyman.com/sites/default/files/nursing/lectures/04-patho-pharm1-pain-08.mp3

VoiceThread

 


Unit 7 Respiratory

Respiratory anatomy and physiology

  • Basic respiratory pathophysiology
  • Respiratory diseases
  • Respiratory pharmacology

Class notes:

Lectures

Respiratory A&P

Respiratory 01 A&PLungs, bronchi A&P.Glucose + O2 –> H20 + CO2http://patheyman.com/sites/default/files/nursing/lectures/08-patho-pharm1-resp-01.mp3Respiratory 02 A&PAnatomy continued.Alveoli –> Increases surface area.Circulation to the lungshttp://patheyman.com/sites/default/files/nursing/lectures/08-patho-pharm1-resp-02.mp3Respiratory 03 A&PControl of breathingBronchoconstriction and dilation“Enhance this: beta-2 stimulation” or “Inhibit this: parasympathetic system”http://patheyman.com/sites/default/files/nursing/lectures/08-patho-pharm1-resp-03.mp3Respiratory 04 A&PDefense of Respiratory TractMechanics of breathingOxygen diffusionhttp://patheyman.com/sites/default/files/nursing/lectures/08-patho-pharm1-resp-04.mp3Respiratory 05 A&POxygen transport in blood.Hemoglobinhttp://patheyman.com/sites/default/files/nursing/lectures/08-patho-pharm1-resp-05.mp3

Respiratory Manifestations

Respiratory 01 ManifestationsDyspnea, Breathing Patternshttp://patheyman.com/sites/default/files/nursing/lectures/08-patho-pharm1-resp-06.mp3Respiratory 02 ManifestationHypoventilation, Hyperventilation, Hypercapnia, Cough, Cyanosis, Chest Painhttp://patheyman.com/sites/default/files/nursing/lectures/08-patho-pharm1-resp-07.mp3Respiratory 03 ManifestationRecapClubbing, Sputum sample, Hypercapnia, Perfusion of lung, Respiratory Failurehttp://patheyman.com/sites/default/files/nursing/lectures/08-patho-pharm1-resp-08a.mp3Respiratory 04 Manifestationhttp://patheyman.com/sites/default/files/nursing/lectures/08-patho-pharm1-resp-09a.mp3Respiratory 05 Manifestationhttp://patheyman.com/sites/default/files/nursing/lectures/08-patho-pharm1-resp-10a.mp3

Respiratory Diseases

Respiratory 01 DiseasesARDSPost op Respiratory failurehttp://patheyman.com/sites/default/files/nursing/lectures/08-patho-pharm1-resp-11a.mp3Respiratory 02 DiseasesAsthmahttp://patheyman.com/sites/default/files/nursing/lectures/08-patho-pharm1-resp-12a.mp3Respiratory 03 DiseasesCOPD: Chronic Bronchitishttp://patheyman.com/sites/default/files/nursing/lectures/08-patho-pharm1-resp-13.mp3Respiratory 04 DiseasesCOPD: Emphysemahttp://patheyman.com/sites/default/files/nursing/lectures/08-patho-pharm1-resp-14.mp3Respiratory 05 DiseasesRespiratory infections: Rhinitis, Sinusitis, Pharyngitis, Bronchitis, PneumoniaPulmonary embolismCancerhttp://patheyman.com/sites/default/files/nursing/lectures/08-patho-pharm1-resp-15.mp3

Respiratory Pharmacology

Respiratory 01 PharmacologyInhalers: MDI, DPI, NebulizerBronchodilatorshttp://patheyman.com/sites/default/files/nursing/lectures/08-patho-pharm1-resp-16.mp3Respiratory 02 PharmacologyRespiratory Anti-inflammatoriesStep up and Step down approachRule of 2sCOPD treatmenthttp://patheyman.com/sites/default/files/nursing/lectures/08-patho-pharm1-resp-17.mp3Respiratory 03 PharmacologyRhinitis treatmentsCough suppresssantshttp://patheyman.com/sites/default/files/nursing/lectures/08-patho-pharm1-resp-18.mp3

VoiceThread - Respiratory A&P

VoiceThread - Respiratory Patho 01 - Manifestations

VoiceThread - Respiratory Patho 02 - Resp Disorders

VoiceThread - Respiratory Pharmacology

Video - Respiratory A&P and Pharmacology


 

Unit 8: Hematologic

  • Physiology of blood
  • CBC interpretation
  • Anemia physiology and pharmacology
  • Blood Products

Class Handouts:

Class notes:

Lectures

Blood Physiology and Lab Values

Physiology of BloodComposition and functions of blood.HematopoeisisLab valuesReview of WBCshttp://patheyman.com/sites/default/files/nursing/lectures/09-patho-pharm1-hematologic-01.mp3WBC review and PlateletsWBC w/differentialANC calculationPlateletshttp://patheyman.com/sites/default/files/nursing/lectures/09-patho-pharm1-hematologic-02.mp3Red blood cells and HemoglobinErythropoiesisHemoglobinLab valuesB12 and Folatehttp://patheyman.com/sites/default/files/nursing/lectures/09-patho-pharm1-hematologic-03.mp3Hemoglobin ContinuedFolic acid continuedIronHemoglobin breakdown productshttp://patheyman.com/sites/default/files/nursing/lectures/09-patho-pharm1-hematologic-04.mp3

Anemias

CBC interpretationThe details of the lab values you need to memorize are slightly different than the podcast. Please refer to the current lab sheet. I will not ask you questions with lab values that are vague.http://patheyman.com/sites/default/files/nursing/lectures/09-patho-pharm1-hematologic-05.mp3Anemias OverviewOverview of AnemiasMajor types and Common Signs and SymptomsPernicious Anemiahttp://patheyman.com/sites/default/files/nursing/lectures/09-patho-pharm1-hematologic-06.mp3Anemias 2Folic acid deficiency anemiaIron deficiency anemiahttp://patheyman.com/sites/default/files/nursing/lectures/09-patho-pharm1-hematologic-07.mp3Anemias 3Post-hemorrhagicAplasticHemolyticAnemia of Chronic Diseasehttp://patheyman.com/sites/default/files/nursing/lectures/09-patho-pharm1-hematologic-08.mp3Anemias 4HemolyticAnemia of Chronic Diseasehttp://patheyman.com/sites/default/files/nursing/lectures/09-patho-pharm1-hematologic-09.mp3

Review

Hematology reviewReview and Worksheethttp://patheyman.com/sites/default/files/nursing/lectures/09-patho-pharm1-hematologic-10.mp3

 


Unit 9: Bleeding and Clotting

  • Physiology of clotting
  • Various clotting and bleeding disorders
  • Lab tests of clotting
  • Antiplatelet drugs
  • Anticoagulant drugs
  • Thrombolytic drugs

Class notes:

Lectures

Bleeding and Clotting

Clotting 1http://patheyman.com/sites/default/files/nursing/lectures/10-patho-pharm1-clotting-01.mp3Clotting 2http://patheyman.com/sites/default/files/nursing/lectures/10-patho-pharm1-clotting-02.mp3Clotting 3http://patheyman.com/sites/default/files/nursing/lectures/10-patho-pharm1-clotting-03.mp3Clotting 4http://patheyman.com/sites/default/files/nursing/lectures/10-patho-pharm1-clotting-04.mp3Clotting 5http://patheyman.com/sites/default/files/nursing/lectures/10-patho-pharm1-clotting-05.mp3Clotting 6http://patheyman.com/sites/default/files/nursing/lectures/10-patho-pharm1-clotting-06.mp3

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